There is some good news for Kala Azar patients. Researchers at the Indian Institute of Technology Hyderabad claim to have developed a method to produce controlled-release oral tablets for treating fungal infections and Leishmaniasis (kala-azar or black fever) that are prevalent in the country. Their tablets were found to release the drug Amphotericin B in a sustained and controlled manner over a period of 10 days. 

Amphotericin B (AmB) is the drug of choice for progressive and potentially life-threatening fungal infections of the abdomen and heart valves, fungal pneumonia, and leishmaniasis, a neglected tropical disease. It is used to treat Kala Azar or black fever, a dangerous and often fatal form of Leishmaniasis, common among the economically underprivileged sections in states such as Bihar, Jharkhand, West Bengal and Uttar Pradesh.

The development of oral, controlled release tablets for fatal fungal infections and leishmaniasis, could help in better management of the disease burden in the country. The development of cures for dangerous fungal diseases and leishmania has been challenging. Prof. Brahmchari who first used an antimony compound for treating kala azar in the nineteen twenties was even nominated for the Nobel Prize in 1929, a statement issued by IIT, Hyderabad said. 

The disadvantages associated with AmB include high cost, toxicity and poor bioavailability. AmB is administered through injection, which results in uncontrolled release of the drug into the blood stream.  There have been attempts to make oral medication containing AmB to control the delivery of the drug and bring down costs.

In order to make controlled-release oral tablets, the drug molecules must be loaded onto a base that dissolves gradually to release the drug over a period of time. 

The research was led by Prof. Saptarshi Majumdar and Dr. Chandra Shekhar Sharma, Associate Professor, Creative and Advanced Research Based on Nanomaterials (CARBON) Laboratory, Department of Chemical Engineering. The team’s work has been published in the July 2019 issue of the reputed peer-reviewed journal Nano-Structures and Nano-Objects. The paper has been co-authored by Dr. Anindita Laha, Ms. Mrunalini Gaydhane.

Speaking on the rationale of using nanofibres to produce oral tablets of AmB, Dr. Chandra Shekhar Sharma said, “Nanofibres – fibres that are a hundred thousand times thinner than the human hair – are increasingly being considered as a medium for controlled release of drug molecules because of their large surface area and porosity. ”

For the first, Dr. Sharma’s team chose gelatine (or gelatin in American terminology), an U.S. Food and Drug Administration (FDA)-approved natural polymer, a form of collagen naturally found in the bones, cartilage, tendon and connecting tissues of animals. Gelatine is biodegradable, nontoxic and biocompatible and is extensively used in food and medical industries.

For the manufacturing method, the team chose a process called ‘electrospinning.’ Electrospinning uses electric force to draw charged threads of the polymer into fibres with diameters in the order of some hundred nanometres.

The IIT Hyderabad team faced a small problem in making gelatine nanofibres by electrospinning.  Dr. Sharma said, “while gelatine nanofibres could be easily produced by electrospinning, their poor structural consistency in aqueous conditions required them to be crosslinked”.  So the team found a way to crosslink the fibres.

Thus, the drug, AmB was loaded to the gelatine before electrospinning, and after electrospinning, the drug-loaded nanofibres were crosslinked with saturated vapors of aqueous glutaraldehyde.  The nanofiber mats so obtained were finally compressed into tablets.

Prof. Majumdar added, “Through careful control of the crosslinking conditions, we could achieve sustained release of AmB over a period of ten days.” The team also found that the nanofibrous oral tablet was stable over a wide range of pH, which means that it would not be destroyed in the gastrointestinal track before drug absorption into the blood stream.

The World Health Organization (WHO) has called for accelerated research and development in new tools for malaria prevention, treatment and eradication of malaria in the foreseeable future. Today less than 1% of funding goes to developing tools to tackle malaria.

WHO has also flagged the urgent need for progress to advance universal health coverage and improve access to services, and better surveillance to guide a more targeted malaria response. The findings have emerged in a report from WHO’s Strategic Advisory Group on Malaria Eradication (SAGme).

“To achieve a malaria-free world we must reinvigorate the drive to find the transformative strategies and tools that can be tailored to the local situation. Business, as usual, is not only slowing progress, but it is sending us backward,” according to Dr Marcel Tanner, Chair of the SAGme.

The group has published the executive summary of its report ahead of a WHO-hosted forum on “Rising to the Challenge of Malaria Eradication” to be held in Geneva on 9 September 2019.

“Freeing the world of malaria would be one of the greatest achievements in public health,” says Dr Tedros Adhanom Ghebreyesus, WHO Director-General. “With new tools and approaches, we can make this vision a reality.”

The health benefits would be greatest among some of the world’s most vulnerable populations. Children under five account for 61% of all malaria deaths. More than 90% of the world’s 400,000 annual malaria deaths occur in sub-Saharan Africa.

The group’s analyses showed that scaling up current malaria interventions would prevent an additional 2 billion malaria cases and 4 million deaths by 2030 – provided those interventions reach 90% of the population in the 29 countries that account for 95% of the global burden.

The cost of this scale-up is estimated to be US$ 34 billion. The economic gain would be around US$ 283 billion in the total gross domestic product (GDP) – a benefit to cost ratio in excess of 8:1.

Global malaria infection and death rates have remained virtually unchanged since 2015. WHO’s World Malaria Report in 2018 revealed that the world is currently off-track to achieve the 2030 goals set out in the WHO Global Technical Strategy for malaria 2016-2030 – i.e. a 90% reduction in the malaria case incidence and mortality rate.

In many countries, access to health services remains a major challenge. Only one in five pregnant women living in areas of moderate to high malaria transmission in Africa is able to obtain the drugs she needs to protect herself from malaria. Half the people at risk of malaria in Africa sleep under an insecticide-treated net and just 3% are protected by indoor spraying with insecticides.

This highlights the need to advance universal health coverage and strengthen health services and delivery systems, so everyone can access malaria prevention, diagnostics, and treatment, when and where they need them, without suffering financial hardship.

The group noted the need to rethink approaches. WHO and partners are already establishing some new strategic approaches to tackling malaria. Last November, for example, WHO and the RBM Partnership to End Malaria launched the “High burden to high impact” approach. This aims to jumpstart progress against malaria by targeting attention to the 11 countries with 70% of the world’s malaria burden – 10 African countries and India.

This complements efforts to secure certification among the countries seeking to eliminate malaria by 2020, the WHO “E-2020” initiative. So far, WHO has certified 38 countries and territories malaria-free.

Most of the tools being used to tackle malaria today were developed in the last century or even earlier: insecticide-treated mosquito nets, indoor residual spraying, rapid diagnostic tests and drugs based on artemisinin.

Promising new diagnostics, medications, insecticides and vector control approaches are being developed, alongside passive immunization therapies such as monoclonal antibodies. The world’s first malaria vaccine, RTS, S/AS01, has been deployed in Ghana and Malawi, with plans for rollout in Kenya.

SAGme is composed of 13 leaders and scientists representing a range of disciplines and geographies. They are supported by representatives from WHO collaborating centers, WHO staff and other key stakeholders.

Nayati Medicity, Mathura, successfully operated and cured Vimla Devi, a resident of Raya, after she was brought in as an accident victim. She was brought into the hospital in a critical condition with severe head and face injuries.    

Ms. Devi was on a motorcycle when she met with an accident and lost consciousness on the spot. Her family members brought her to Nayati Medicity, Mathura, where she was put under the care of Dr. Ravindra Srivastava and Dr. Vimal Kumar, Senior Consultant, Neurosurgery. 

Medical diagnosis revealed that Ms. Devi’s facial nerve bone was injured, leading to a deformed face along with multiple brain clots and head fracture. The fracture and clots were successfully treated through head surgery performed by the two senior doctors and their team. 

Ms. Devi was forwarded to the ENT team for Otorhinolaryngology. Analyzing her condition, Dr. Manish Jain, head of the department of ENT at Nayati Medicity, said, “Ms. Devi’s diagnosis revealed that her facial nerve was under constant pressure due to the impact from the accident and consequently, some broken bone pieces were stuck in the nerve. These pieces compromised the nerve function, made it nearly negligible and caused her face to droop on one side.”

Observing the complexity of the situation, Dr. Jain recommended surgery to her family members. After their consent, Dr. Jain and his team performed a successful surgery, where they removed the pressure on the nerve and slowly extracted out the bone pieces stuck in the nerve. 

With the help of two separate surgeries from the neurology and ENT department, Ms. Devi’s health condition continues to experience a steady improvement. Currently, her head injury has been cured, and she is able to close her eyes properly. In addition, the stroke-like impact on her face has been cured to a significant extent and could recover from the impact over the period of time.

Talking about his experience with Nayati Healthcare, Ms. Devi’s husband said, “My wife received immediate medical treatment due to the fact that multiple, good quality services were collectively available under one roof at Nayati Medicity. I would like to express my gratitude towards the doctors and their team of the neurosurgery and ENT department for giving her a new life.” 

A research study has revealed that 67 percent of care leavers –young people who have left the state or NGO-run childcare institutions once they reach 18 years of age – are not aware of aftercare provisions. , reveals a research study conducted by NGO Udayan Care.

The study conducted by Udayan Care, a non-governmental organization, said aftercare is the support provided to young people over 18 years of age after they leave childcare institutions to help them in community integration and to live an independent life. Care leavers are entitled to this support as mandated by the Juvenile Justice (Care and Protection of Children) Act, 2015 its Rules of 2016 and the Child Protection Services, (earlier known as the ICPS).

The study ‘Beyond 18: Leaving Child Care Institutions – Supporting Youth Leaving Care’ was conducted with support from UNICEF, Tata Trusts, Deep Kalra (CEO, Make My Trip India) and participating state governments. It captures the voices of 435 care leavers and over 100 key informants including functionaries working on the ground on child protection in Delhi, Gujarat, Karnataka, Maharashtra, and Rajasthan. UNICEF was the lead technical partner and state liaison for the study, which for the first time in India gives a voice to care leavers.

Growing up in childcare institutions has an impact on the education, skills and social stability of young people and does not prepare them adequately with the skills for becoming an adult. 

The study points out the lack of participation and non-inclusion of children in planning their future, with 44 percent care leavers accepting that they were not consulted in the development of their Individual Care Plan, a pathway planning process mandated by the Juvenile Justice Act.

Shireen Vakil, Head – Policy and Advocacy, Tata Trusts stated, “The absence of a continuum of care services and a holistic rehabilitation plan impedes children in need of care and protection from living a productive and dignified life.” 

“I came to the childcare institution (CCI) when I was 12 years old. I got emotional support and guidance for my career, and I became an engineer. When I was asked to move out of the childcare institution, I was emotionally broken. Since the age of 12, I believed that the institution was my home and family. After I moved out I always felt a sense of insecurity. I would like to request everyone to hear our voice so that we can also lead happy independent lives,” said Ramesh* a software developer in an MNC company.

The study also highlights the gender disparity in the present approach to rehabilitation of Care Leavers. 63 percent of the female care leavers, as against 36 percent males, do not have an independent source of income despite similar educational qualifications. Only two states – Delhi and Maharashtra – of the five States studied have aftercare home for girls. Largely, the approach to female care leavers is focussed on getting them married or sending them to destitute homes or Swadhar Grihas rather than empowering them to be financially independent.

Aneesha Wadhwa, Executive Director of Udayan Care, called for recognition of care leavers as a vulnerable category under various central policies such as the National Youth Policy 2014, the National Policy on Skill Development and Entrepreneurship 2015 and other policies for youth.

The study also calls for mandatory transition planning as part of the implementation of Individual Care Plans for all children living in childcare institutions from 14+ years to ensure their preparation towards independent living and develop a trajectory of change ensuring that they are supported by the state.

The juvenile justice system is not prepared for Aftercare as there are deficits at the level of information, access, skills, knowledge, and training on transition planning, human resources, and budgetary investments. 

Importantly, there is no database of Care Leavers, exiting Child Care Institutions, and no follow up of these youth to monitor their wellbeing and rehabilitation. Care Leavers have no one-point contact for access to Aftercare information and services. z Female Care Leavers are at a greater disadvantage than male Care Leavers in the present gendered approach to rehabilitation and existing social realities, the study says. 

A star name Daniella Abraham has risen from south Florida. She has been a show-stealer of every private party of the celebrities because of her cooking. Daniella Abraham, who is popularly known as Chef Danie, is the young lady who is among the most favorite Chef of the Hollywood peeps. In just a few years she has earned a very good reputation in the culinary industry. She has served many A list of Hollywood celebrities and sportsperson like Drake, Oprah, Antonio Banderas, Kylie Jenner, Sean “Diddy” Combs, Pharell Williams, Dj Khaled, Louis XIII, Reebok, Godiva, the Omran family of Saudi Arabia among many others.

Chef Danie’s interest in cooking developed at such a young age. She was raised by a hardworking single mother. Anytime her mom would get the free time she would cook with her and learn the basics of cooking. All of these moments with her mother made her fall in love with good and the art of cooking. Later on, even though she got the scholarship to go to the University of Miami her interest didn’t fade away. She took cooking classes along with her studies because she had made her mind to become a chef.

Danie started from the very bottom. After getting training from Le Cordon Bleu she started doing baby showers and other small house parties for friends and people who wanted her service. She started earning Lil money from these works. Then she came into a client who gave her a website where she posted her experiment alcohol cake which eventually went viral and made her famous and it kind of gave her stairs which led her to fame and success and changed her life.

Today Chef Danie is a super popular celebrity chef who gives star service to private parties. All of this was possible because she listened to her. Even though the darkest day she didn’t lose hope and kept working for a dream and came out as a successful example for every woman out there. Chef Danie is the woman who has made a difference with achievements and inspired so many of us.

A start is never easy. It brings along with itself lots and lots of hardships which makes people wonder whether the decision taken by them was right? Will, they will succeed? Or will they ever find themselves at a place where they have been imagining themselves? This is the place where various seekers stop what they seek for and back out without fulfilling what they have been looking after. 

But this is the first half, what about the other one? well, the other half consists of people like Rohitash Jadhav who started with Digital Marketing and moved ahead to “Viral Mania” and in various other fields which made the people call him out with varied titles such as Influencer, Youtuber, Social media gig, etc. His Digital Marketing head and experience knew what people demand and he presented them with something which was truly factual and asked for. What next is obvious for sure, he gained recognition. Recognition from the current Chief Minister of Madhya Pradesh Mr Kamal Nath. The CM was proud to reward such a young head who wanted to create a change in society. All of this was just a start and a lot was waiting for him in his future.

Rohitash became a part of a Social event which was conducted with the name of “Narayani Namah”to show the women empowerment. He was called upon to attend the same and was obliged to be a part of it. He being a part of Digital Marketing company where women outnumbered men, provided support to the women’s by all means, where his efforts came in the limelight and he was truly rewarded by making him a part of events like “Narayani Namah” and varied such events where he tried his best to serve his purpose and help people by every means he can.

In one place he served his purpose by being physically present on such events and other was his Youtube channel and Facebook page by the name of “Viral Mania” which on and all tried serving people through the interesting facts and news which people remained debarred from. The idea of change was working and soon Rohitash received opportunities which he never expected so early. His page was approached by Celebrities who got their content viral with more than a million views and these million views soon changed from days to hours. 

Within hours of upload, the contents started receiving views which were more a million for sure. Apart from this, Viral Mania also served many Political leaders like “MP’s and MLA’s” who wanted their campaign to reach the public and make them aware about such initiatives are taken by their political leaders.

The page got wide and voice of what was served reached many. Several people received news and varied benefits through Viral Mania, which truly became unstoppable. Even there where E-commerce Portals which approached Viral Mania with their needs and on today’s date the same is being handled by the page and Youtube channel getting the portals for what they demanded.

The Youtube channel of “Viral Mania” writer and creator of facts and Facebook page of “Viral Media” which was dedicated to providing the public with amazing facts and news of entertainment reached out to the public and captured their hearts. Not only this, they tried their best to provide best for all the Politicians, Public and the Celebrities who wanted to reach the public with all their heart and a proper truth. No opportunities were missed and neither was the chance to influence. Every crowd learned some or the other thing and was thankful to Rohitash and his initiatives which made them learn something new and this is how this Digital marketer by his journey became a Youtuber and a Social Media gig which was truly appreciated in all fields. 

Dr Mukesh Bangar is an author, entrepreneur and a scientist who has solved three mysteries of the world which has left everyone in a great surprise. He was born and brought up in a small town of Yavatmal, Maharashtra. Belonging to a middle-class family, his father is a retired government servant while his mother is a housewife. Since his childhood, he was intrigued by research. How does a motor engine work? Be it water pump, calculator, watch or a computer, he had questions about these gadgets and had a curiosity to know about its working mechanisms. He was very fascinated with questions like the world’s existence, the purpose of life and life after death. 

He began to find its answers and after extensive research on the internet for 8 long years, he came up with solid rational and reliable conclusions. His first question was ‘The origin of the universe’ and how the world started? With extensive research, Dr Mukesh proposed a new theory where he explained the origin of the universe and revealed that it is the Theory of Real Space-Time Integration. His theory started with the topic perception and ended with the law of the universe. The law stated that ‘Universe is emergent and symbiotic by inheritance.’ The greatest finding of his research was, ‘Zero is a mathematical value having no existence in real but nothing has an existence in reality and any existence can transform into other existence.’ Moreover, he went on to discover a similar diagram of Nobel Prize winner scientist Feynman’s diagram which explains the exact origin of the universe.

As a child, he always pursued to become an engineer but became a doctor because of his mother’s dream. During his education, Dr. Mukesh came across a mysterious organ human brain. He was keen to know how the human brain works and his second mystery question was ‘What is consciousness and its nature?’ During his finding, he learned about neural networks, brain anatomy, mind philosophy and when he drew entire brain structure on single wall, he discovered Integrated Sensory Motor Loop (ISML) which is responsible for consciousness and he also proposed cognitive model of consciousness in his next theory that was ‘The cognitive model of consciousness in Toto.’

Last but not least, the third mystery is his invention – Awareness Processing Unit (APU) or a self-programmable AI. After the discovery of ISML, his passion for machines saw him learning about computing, programming languages and chip designing. During this research, he founded the home automation startup. He applied his discovered algorithms into the machine and built a prototype processor, which saw the invention of APU. He simultaneously built another machine using wireless technology which was also self-aware, self-programmable and self-governed AI. 

The three mystery questions and inventions by Dr. Mukesh Bangar are revolutionary for mankind. This research is the biggest achievement of his life and he believes that by using this technology, many unrealistic dreams of humanity will come true of which one is living on other planets. Isn’t it unbelievable?

Manaenkova Natalia is a known model and was raised in Moscow, Russia and since her childhood, she had the stars in her eyes and always wanted to fly high. She understood from her young age that glamour is the only industry that can help her scale new heights. Thus when she was in college, she stepped into the world of modeling working with different brands and showcased herself over different ramps to become the new face of the brand in different commercial and print ads.

As time passed, she kept on expanding her wings and soon started getting offers pouring in from big brands like L’officiel Baltic, Kazakhstan; In Style Moldova; Vogue Ukraine; MaximAfrica; Playboy Russia, Ukraine, Italy; and GQ Mexico. She is now the part of many cover page of these magazines giving her much air and exposure making her the emerging lady in the glamour world over the global platform. Besides, she also got the chance to work with top stars of the Russian show business. Thus has given a huge exposure in the world of glamour landscape.

She is now the part of the Large-scale exhibition venture called “Naked World” which brings all the beautiful faces across the world giving them a bigger platform for fashion and glamour. All these exposures have made her a stable model in the glamour world, and we now see Manaenkova Natalia holding her exhibition called Cold Air at the Artplay Design Center. This was a photo exhibition that was meant to offer the local artists from platforms like theatre, movie, and music to showcase their talents through photos. The project also addressed the sufferings of people caused by hostilities.

The show also involved several popular faces from Russia including the popular Moscow artists, actors, musicians and TV hosts including Alyona Vodonaeva, Artyom Korolev, Tatyana Kotova, Kristina Asmus, Odin Byron, and Maxim Radugin to name a few. Many public figures in fashion show business have appeared before the audience giving a new artistic image. This speaks a lot about the lady who is all set to rule the world of glamour, fashion and creative industry.

Great money investors are like rock-stars of the financial world. The greatest investors not only make a fortune off their success, but they also help millions achieve similar returns.

Mahin is not a common name in the stock market. This genius has made a massive name in a short time in India, Dubai, and Singapore. He is currently the most exceptional investment guru for many entrepreneurs and B-town people. His every seminar is packed with A-grade people.

It is always great to learn from people who have achieved in life. Many investors believe in Mahin because he has achieved so much in a short time with his expertise. Today many young ones want to become wealthy like him.

Many say he is going to be the next warren buffet from India. His skills investment skills are way ahead than average in the market. He is leading his way to top entrepreneur from India, who is famous in celebrities from various fields. 

He will be a self-made millionaire and youngest too from India for sure. He is already shining in India, Dubai, and Singapore and his every seminar is packed with top celebrities. After all, everyone today wants to invest in the right place in this slowdown.

Mahin is planning to expand his business to western countries. We will see VENTESKRAFT GLOBAL shine all over the world with their experts mentoring top heads around the world.

Looking at his achievement, we will see a story come on in his life how an ordinary investor became an entrepreneur and mentor of top heads around the places. He too can write his autobiography after all he is a renowned author also. Mahin is a fabulous person, very down to earth and lovable personality. This guy has all plus in him, which is taking him to new highs in his career, and he is expanding more and more places with his business.

Music Producers write, arrange, produce, and record songs, whether they are shaping around the Sound of other artists album or producing beats or melodies for their projects.

With the growth of home recording technology and boutique recording studios, many producers find themselves pulling double or triple work as studio owners and Sound engineers.

From India to Dubai and Dubai to London, Aly Raza Beig age 19 is creating lots of Buzz for promoting and creating good music with his talent.

Music runs in his blood, Aly Raza Beig was only 12 when he first produce a song. Wow in school when boys don’t know how to seat in bench, and he produced a song. It shows his talent and love for music from his childhood.

 Aly Raza Beig is a self-made music producer, he is known as Slapvibe from 2015. Aly Raza Beig is known for producing grooving music. He is expert in Tech House, Techno and Pop music.

Aly Raza Beig was born in the dream city of India – Mumbai and raised in Dubai and now studying in London. Wow, three different places in young age India, Dubai and London. It means he has knowledge of three cultures; surely, it will help in producing fresh music. 

Aly Raza Beig loves to make groovy music which can make people dance on their feet. His primary focus is always on Sound of the music. He knows how to mix up things and make a sound which can be like by every age audience. 

Aly Raza Beig works hard for hours in his office. Don’t know he manages things. He is just 19 and managing this much in tender age is commendable. May be his passion and love for music is helping him to push hard for his career. 

Aly Raza Beig feels there is a lot of work that goes into being a producer outside of the studio such as attending rehearsals, meeting, writing, and going out for shows. He is thankful to social media for helping him to connect with more artists than ever. But still, he feels in-person interaction will never be replaced. Half of producing is the music; the rest is sales.