Life is not that much tough when you have the guts to fight against the odds. Many Indian middle-class people have shown their strength to the world as an emerging talent in various fields. 

Mumbai is a place of dreams where every day, thousands of people come to the city to achieve big in their life. Tushar Yuvraj Kamble famous name from Mumbai who was not born with a silver spoon but he never complained. He made it big with his passion and hard work to make it big in life.  

Tushar is a believer he gives his 100% in whatever he does in life. He is an award-winning painter who has won hearts of many like Yash Chapora and other famous B-town celebrities with his paintings. Tushar is not an ordinary painter he is class when it comes to putting colours on canvas. A beautiful story can be made on his life related to his Painting and his professional career. Painting is his hobby and passion too. He always takes some time out from his busy schedule for his Painting. 

Those who know Tushar personally knows pretty well that his first love is painting in life and then photography. This two thing makes him happy, and he has mastered himself in his hobbies.

He is an IT specialist and works in Dubai. He single-handedly arranges work of five projects. You can call him a one-man army. He has learned a lot in Dubai, especially in IT. He is pretty closed to Dubai’s top names because of his expertise in IT.

What good about Tushar is whatever he does in life he does it with perfection. He never does work with half heart. You will always see him giving 100% in his work, and this is the reason why he is achieved this much in his life.

We recently show a movie on Raja Ravi Varma in B-town. The same story can be made on this guy. His Paintings are just excellent, and he is improving day by day with his experience. When you see him painting, it’s like he is living in a different world were only beautiful colours can be seen and happiness.

It is so good to see an artist who is living a beautiful life by learning new things in IT and enjoying his passion and love of Painting and Photography. He can be the next big name in IT in the near future looking to his growth. Aah! You might get confused by reading this painter, photographer or IT. But this guy has forced us to write on him as he is superb in every department. 

His life philosophy is simple, and he believes in working hard and never left things in halfway whatever he does, he complete that with a magnificent result. He is a man of his words too once he says he will do it means there will no excuse from his side.

Vanit Bakshi from Punjab but living in Moscow from more than last 1 decade sizzled the musical world with his astounding persona and charm and mesmerizing voice a heart touching lyricist/ songwriter.

Vanit has worked with some well-renowned banners and has left no stone unturned to make his entry in Bollywood by growing as an Independent Artist by his continuous efforts.

Extracting immense fame and fan fam from a number of albums, Bakshi is all geared up for his upcoming projects in the pipeline. 

Vanit has written a number of praise songs and poems for b’towns ace celebs like Imtiaz Ali, Tabu, Mohit Chauhan, Sonu Nigam, Alka Yagnik, Ayushmaan Khurrana and many more while his meeting with them during some film festival and musical shows in Moscow.

Vanit Bakshi has also contributed to the social welfare of the country via his songs such as Babul, Maa, Hamara Desh,  Gussa Hai Bharat and many more. His most popular song was Hanju : Tears of Happiness which was released by Zee Music and was Feat.Svetlana Tulasi who is a well-known name in Lovers of Classical / Kathak Dance. Another hit given by Vanit Bakshi was Sajda and cover of “Teri Mitti” from movie Kesari.

Vanit Bakshi’s most awaited song  “Akhaan Jaa Rawayiaan”  will be out soon in which he has collaborated again with Svetlana Tulasi and Surely! his fans can’t wait for it.

Just because your life changes doesn’t mean that your deepest passion has to. Very rare to see such people who follow this rule in their life and the one who has followed has set an example which needs to be praised. As this person has reached the greatest level of success one could not achieve at a very early age as he is just 22 now. His hard work, persistence, and determination really should be appreciated with a pat on the back.

The Pillar of one of the leading Digital Marketing firm DIGIHAKK, Sarvesh Pancholi, born on 12th August 1996 and is based out in Indore. He has faced a lot of challenges to build this empire called DIGIHAKK. They have built some great techniques related to digital marketing. They have spread their roots in Udaipur, Indore, and Ahmedabad by now and focusing on extending their concepts all over so that they can train the youth to grab some exciting position and gain experience in Digital Marketing. The real focus is to build opportunities for others.

There has been a lot of struggle in his life but nothing stopped him. He started off from a very early age. He established his first company when he was just 16 named “SCHOOL SECURITY” which provides training in ethical hacking and services. But this is not been achieved without challenges. The biggest challenge for him was having less experience in this field and most importantly a lot of financial crisis, but by the time he was 18, he reached another milestone by starting off with 3-4 startups. Now that’s a bigger achievement at this less age.”Age factor was an issue. I had to drop out my college and take up this big Risk at the age of 18 which helped me build 3-4 startups. But that failed and now I am proud of myself that I could establish a giant in the Digital Marketing field which is DIGIHAKK”, says Sarvesh.

Learning should never stop. Gaining knowledge and sharing of knowledge is most important in life to reach success. He at present also self trains himself to be better each day by polishing his skills to face new challenges. Hats off to this young man who was been confident in himself believed in his dreams and had a courage to take up the risk.

There is something special to be your own boss and build your own empire. At some point, one needs to start from scratch, and Neha Chatlani is a prime example of it. Based in Bangalore, she holds a degree in MBA and had been a corporate HR recruiter for more than 4 years. While working, she realized that her job had become monotonous and did not give her the right platform to channelize her creative side. 

When being her own boss was more important to her than following someone else’s orders, she decided to take the plunge with YouTube. Along with her job, she simultaneously managed her YouTube channel to unleash her creative side. Juggling multiple things at the same time had become a tedious task. With time, her inclination was shifting towards the creative field in Social Media. She had to make a choice, so she bid adieu to one of the Big 4 audit firms and chose social media as her full-time career.

Through Instagram, she showcased how comfortable outfits could be made stylish, keeping in mind the college and workplace dress codes. Her main focus was street style fashion for which she got an overwhelming response. She started connecting more with her audience through her social media platforms and creating relatable content that suited their needs. Her styling was quickly noticed by brands like Fabindia that invited her to conduct a styling masterclass at one of their branches. She also started a blog called “The Talky Trails” that diversifies into a lifestyle, food, and travel. 

Her main motto which she strongly believes in is “Fashion need not be uncomfortable to be stylish”. As a top fashion influencer, she has worked with more than 500 brands including Reebok, Myntra, Maybelline, Nykaa, Nissan, Holiday Inn and many more. Today she is one of the most successful content creators on social media in Bangalore and is also recognized as a top blogger on Trell – a visual blogging platform.

In today’s time, blogging as a career has become one of the most sought professions. People pursuing engineering or any other degree tend to shift towards the world of blogs. Same happened with Nivrity Das who is one of the most influential bloggers today. Hailing from the city of joy, Kolkata, she has been a school topper and has done B.Tech in electronics and communication. However, she has a deep affection for fashion, beauty, and lifestyle; and her blog is a reflection of whatever she does.

Her blogging journey was a random thought which started off in college. Nivrity had always been intrigued by speaking her heart out and she kept herself up to date with the latest style and fashion trends. Not just experimenting with looks, she also had been very fond of getting clicked. Be it anchoring or managing events at the college, her love to express herself saw her in becoming a top blogger/vlogger.

Speaking about her progress, Nivrity Das believes that her graph as a blogger has been consistently increasing. With just three years in this field, she collaborated with more than 200 brands and is one of the most popular bloggers in Kolkata. Apart from Kolkata, she has done numerous events in Mumbai as well. The thing which interests this fashion influencer the most about her career is to showcase what she loves – be it any travel destination, a lifestyle product or fashion outfits. 

Moreover, Nivrity’s beautiful looks and immense dedication towards work can completely be seen in her content. With having more than 270K followers on Instagram, her feed shows how passionate she is about travel and makeup. Her styling ideas also go with the latest trends which have caught everyone’s eye on social media. If you are a person who loves traveling and follows the latest fashion and lifestyle trends, check out her Instagram feed right away.

Expressing gratitude, she was quoted saying, “I am really grateful to God. Whatever I have got the recognition today is because of the immense love of all my followers.” She did not forget to mention her constant support, her photographer cum confidant, Jyotika Baijal who has been her backbone in creating such marvelous content.

In the 21st century, you need to be the best to beat the giants of this world. We often see so many young talents who have to change the definition of business. There are many talents today who are under 30 and ruling the world like a boss and also return this goodwill back to their community through community service and nonprofit work. 

CEO Ahmad Rashad, a renowned entrepreneur, has made his name from starting his first business with a $10,000 Loan and turned this into millions in a short period of time. Rashad was in 11th grade when he decided to start a company called “Cargado”, which was an energy drink company. At just the young age of 14, Rashad was honored to receive his first major award, the Rice Award. It was his privilege to be recognized at such a young age for all his hard work. 

Next, Rashad ventured into the entertainment industry, but he quickly realized that route was not for him. Then came his stock market journey, where he learned about ForEx and trading. Through his profits he received from trading, he acquired multiple streams of income. Rashad not only trade, but also has residential listings on Airbnb. Furthermore, Rashad has built his own Shopify stores. His earnings grossed $1,00,000 in 2018 and more than 620 people endorsed him and his business. 

After achieving such high success in Forex, Rashad than started his own credit company called “Elite Credit and Business Services.” Through this business, he was able to help individuals receive 3.2 million in business funding. 

 With all the abundant blessings Rashad has received, he believes that it is imperative that he pour these blessings back into his community. He believes in earning, but he also believes in giving back to his community and helping those less fortunate. Rashad has organized many charity events around the city of Atlanta. His most recent event was a back to school giveaway for the kids in which he gave out school supplies, a $500 check, book bags, speakers, headphones and more! 

Rashad wants to be an inspiration to children and show them that they can achieve anything they put their minds to, no matter their age. Rashad is still very young but has accomplished many goals. He wants to teach others how they too can change their lives and make a difference in their communities! Through hard work and dedication, you can achieve anything and Rashad is a prime example of this.

“It’s easy to express but difficult to influence”.

What requires is an ability to influence people, to bring a change in their ideas, perspective and importantly their opinion that what matters a lot. 

Nowadays people have chosen social media which is serving as an independent platform for them to express themselves and influence others. Among many renowned influencers, the first name that strikes to the mind is of the young talent of Bangalore “Sayyed Sohel Torvi”.

Sayyed Sohel Torvi is a 26-year-old entrepreneur, influencer and a magnificent motivational speaker. He is having a large scale Granite export business. Owing to a company named Ababil Granite Pvt.Ltd and have a healthy business relationship with well-developed countries like China and Taiwan. Unlike other Influencers, his modus operandi is somewhat different and appealing.

His positive perspective about life stimulates him to create motivational contents on social media. Commendable oratory skills leading him on the path of becoming an ideal example for the youth of our country. Besides a successful entrepreneur, he is a man of values. He believes in encouraging and inspiring others to hustle hard day and night and achieve the target. His goal is not only to be a successful entrepreneur of this era but also to leave an impact on an ideal number of people through his charismatic temperament.

It is said that a good leader should possess the influential quality to guide his followers, we have a dazzling exemplar “Sayyed Sohel Torvi aka Suhail Rasool”. Yes! His influential disposition made him won the NDIA Leadership Award 2019, that’s sounds amazing.

His power of words and way of expressing himself segregate him from the crowd and making him one of the most puissant personality of the age. From consuming a lot of values and life lessons from the motivational content he has proved himself as a man of his words in the eyes of innumerable people.

Beta-amyloid plaques, the protein aggregates that form in the brains of Alzheimer’s patients, disrupt many brain functions and can kill neurons. They can also damage the blood-brain barrier — the normally tight border that prevents harmful molecules in the bloodstream from entering the brain.

MIT engineers have now developed a tissue model that mimics beta-amyloid’s effects on the blood-brain barrier, and used it to show that this damage can lead molecules such as thrombin, a clotting factor normally found in the bloodstream, to enter the brain and cause additional damage to Alzheimer’s neurons.

“We were able to show clearly in this model that the amyloid-beta secreted by Alzheimer’s disease cells can actually impair barrier function, and once that is impaired, factors are secreted into the brain tissue that can have adverse effects on neuron health,” says Roger Kamm, the Cecil and Ida Green Distinguished Professor of Mechanical and Biological Engineering at MIT.

The researchers also used the tissue model to show that a drug that restores the blood-brain barrier can slow down the cell death seen in Alzheimer’s neurons.

Kamm and Rudolph Tanzi, a professor of neurology at Harvard Medical School and Massachusetts General Hospital, are the senior authors of the study, which appears in the journal Advanced Science. MIT postdoc Yoojin Shin is the paper’s lead author.

Barrier breakdown

The blood vessel cells that make up the blood-brain barrier have many specialized proteins that help them to form tight junctions — cellular structures that act as a strong seal between cells.

Alzheimer’s patients often experience damage to brain blood vessels caused by beta-amyloid proteins, an effect known as cerebral amyloid angiopathy (CAA). It is believed that this damage allows harmful molecules to get into the brain more easily. Kamm decided to study this phenomenon, and its role in Alzheimer’s, by modeling brain and blood vessel tissue on a microfluidic chip.

“What we were trying to do from the start was generate a model that we could use to understand the interactions between Alzheimer’s disease neurons and the brain vasculature,” Kamm says. “Given the fact that there’s been so little success in developing therapeutics that are effective against Alzheimer’s, there has been increased attention paid to CAA over the last couple of years.”

His lab began working on this project several years ago, along with researchers at MGH who had engineered neurons to produce large amounts of beta-amyloid proteins, just like the brain cells of Alzheimer’s patients.

Led by Shin, the researchers devised a way to grow these cells in a microfluidic channel, where they produce and secrete beta-amyloid protein. On the same chip, in a parallel channel, the researchers grew brain endothelial cells, which are the cells that form the blood-brain barrier. An empty channel separated the two channels while each tissue type developed.

After 10 days of cell growth, the researchers added collagen to the central channel separating the two tissue types, which allowed molecules to diffuse from one channel to the other. They found that within three to six days, beta-amyloid proteins secreted by the neurons began to accumulate in the endothelial tissue, which led the cells to become leakier. These cells also showed a decline in proteins that form tight junctions, and an increase in enzymes that break down the extracellular matrix that normally surrounds and supports blood vessels.

As a result of this breakdown in the blood-brain barrier, thrombin was able to pass from blood flowing through the leaky vessels into the Alzheimer’s neurons. Excessive levels of thrombin can harm neurons and lead to cell death.

“We were able to demonstrate this bidirectional signaling between cell types and really solidify things that had been seen previously in animal experiments, but reproduce them in a model system that we can control with much more detail and better fidelity,” Kamm says.

Plugging the leaks

The researchers then decided to test two drugs that have previously been shown to solidify the blood-brain barrier in simpler models of endothelial tissue. Both of these drugs are FDA-approved to treat other conditions. The researchers found that one of these drugs, etodolac, worked very well, while the other, beclomethasone, had little effect on leakiness in their tissue model.

In tissue treated with etodolac, the blood-brain barrier became tighter, and neurons’ survival rates improved. The MIT and MGH team is now working with a drug discovery consortium to look for other drugs that might be able to restore the blood-brain barrier in Alzheimer’s patients.

“We’re starting to use this platform to screen for drugs that have come out of very simple single-cell screens that we now need to validate in a more complex system,” Kamm says. “This approach could offer a new potential form of Alzheimer’s treatment, especially given the fact that so few treatments have been demonstrated to be effective.”

The research was funded by the Cure Alzheimer’s Fund and the JPB Foundation.

Venice is a city in northeastern Italy and the capital of the Veneto region. The place was discovered in 421 AD by the Celtic people who used to live along the coast. The city is overwhelmed with the architectural mojo and the subtle art of the places.  Built on water, Venice has 1000 years old piles of wood balancing the weight of the buildings which makes the place to live for, thrive for, remember for and be uncertain from time to time. The city is known as “Queen of the Adriatic”, “The City of Water”, “The City of Masks”, “City of Bridges”, “and City of love”.  And if you are planning to visit the city any time soon, then this article is mist read one. In this article, you get to know five best fascinating places to visit in the city which one can’t afford to miss.

So here are the places which you must visit if you are in Venice

Capture the historic site from Rialto Bridge

The city is filled with richness and the iconic beauty of the bridges. There are around 400 bridges in the city, however, only 4 to 5 bridges are there which connect the great Grand Canal. The Rialto Bridge is the oldest bridge. It links the two crowded cities and also the Grand Canal. Standing over the bridge one can capture the historic site; watch the gondolas and boats passing under the bridge, the adjacent fresh market, and Bartolomeo. It’s a place where tourists can stand for long hours just staring at the marvelous beauty of the city.

Take a thrilling and romantic Gondola ride in the Grand Canals

Venice is known for its canals. Out of the all, the Grand Canal is the icon of Venice. Thrilling and romantic Gondola ride in the Grand Canals makes it adventures for the wanderlust and couples. Not only this, travelers enjoy the view of the Venetian Gothic and Early Renaissance facades of the palaces that come off the sides.

Admire rich collection of Venetian paintings at Gallerie Dell’Accademia

If art is what makes artists wealthy then Gallerie Dell’ Accademia is what makes Venice rich.  Venice is not only known for its beauty, love or beautiful sights but it is admired for the art of living, the art of engaging and art of accomplishments. Gallerie Dell’Accademia is the most authentic art gallery and one of the famous places in the city. The Gallery is known for a rich collection of Venetian paintings. The paintings are arranged chronological order so that one can compare the evolution of art forms of the medieval period. Venice is historic and without appreciating the art makes it vulnerable. 

Get mesmerized by size and décor of Santa Maria Della Salute

If going to Venice, how can you miss visiting the largest and biggest church in the city? Santa Maria Della Salute is one of the largest churches and therefore it is one of the important tourist attractions in the City. This Roman Catholic Church is located by Punta Della Dogana between the Grand Canal and the Giudecca Canal. It comprises of domes, bell towers, façade decorated by statues of the four evangelists. The objects of art housed in the church bear references to the Black Death. Well, it’s the best place to go back and forth from faith to fear. 

Do visit heart of the city, St. Mark’s Square

St. Mark’s square is the heart of the city. The place brings people together with tourists, traveler’s strolls, drinks coffee, and stops to chat, meets friends and tour guides. One gets lost in the architectural magic that depicts true engineering. Three sides are framed in arcades, beneath which has fashionable café and shops. It is a mixture of maths and art. For the whole overview of this busy piazza, one can go to its top or the top of the Torre dell’ Orologio.

The city of Venice is one of the most visited places by wanderlust. Its architectural mojo, the beauty, cultural impression, various canals, attractive artwork all fascinate travelers. So, if not this time, do plan a visit to this vibrant place and its historic and breathtaking site.

(The author is  Founder, WIYO Travel)

Ashish Sardana is a 29-year-old multi award-winning Punjabi Musical Artist from North India(Punjab) had released 12 single tracks till now Deemed as one of the Punjabi hottest talents. Ashish Sardana is launching himself into the forefront of the industry with acclaim.

Ashish Sardana talent has found himself performing to sold-out audiences at some of the Iconic Punjabi videos.

Ashish Sardana is a singer, cricketer, Actor, and Music producer and list goes on.

Ashish Sardana was since childhood a talented kid although he was a good cricketer even played for the district, state level and national level from Haryana. After this, he was doing a job with HDFC Bank. But his passion is in music more than other activities. Then he did his music degree from Allahabad University and extra music classes from his guru.

His passion changed his entire life. He falls in love with the music and made his mind to make a career as a Musician.

Ashish Sardana got his first song ”Sada Pyar” in 2015. Written by goldy dhanoa, 2nd song in 2015 with the collaboration of Sharry Mann company yaar anmulle records for his songs(“Rotian” which is written by goldy ) become a good response and helped him get recognition Career and his popularity.

Ashish Sardana got his first break in 2016 with the collaboration of Aman Dhillon who written the song Music Lil martin released from yaariyan records for his song ‘Headline ‘ become a hit or bigger hit with he gets instant 2 million viewers n Still Hold in million on youtube views.

He became hugely popular and from then on he became unstoppable back to back single tracks as follows :

VADDA TARA song in 2017

from the show MEHFIL MITRAN DI

written by SINGGA

music by lil martin

Released from BABBU MAAN COMPANY 

HEY YOLO 

KILLER LOOK SONG in 2018

FROM BABBU MAAN SHOW

AA CHAK 2018

Written by AMAN DHILLON

Music by Lil martin

Released from BABBU MAAN COMPANY 

HEY YOLO

BASS SONG in 2018

duet wid AMAN DHILLON

written by SINGGA

music by MAVI SINGH

RELEASED FROM YAARIYAN RECORDS

COUPLE SONG ( LOVE SONG ) IN 2018

Written by SINGGA

Music by MAVI SINGH

Released from ART ATTACK RECORDS 

MAAHI VE SONG in 2018

written by rohit n music by candy beats

Released from TORONTO RECORDS

TRUE LOVE SONG in 2018

written by dil khedia

Music by ashish sardana (mr shah)

Released from YAARIYAN RECORD 

DIAMOND YAAR SONG in 2019

again from BABBU MAAN SHOW

AA CHAK 2019

Music by ashish sardana (mr shah)

Lyrics by DEEP SIDHU

RELEASED FROM SAGA MUSIC

JEANA WALIYA SONG IN 2019

Written by DIDAR 

Music by ROX A

FEATURING by JAGGI KHAROUD

released from RIZER MUSIC

KANGNA (love song) IN JULY 2019

Written by DIL KHEDIA

Music by STREET BOY N DJ VISHAL 

RELEASED from URBAN DESI RECORDS 

Since the Ashish Sardana has done the various projects as single tracks

Then he come up with the live interviews with various tv channel and radio like rubaru channel, apna punjab, shere punjab , chardi kala tv live ,some  respective radio stations.

Ashish Sardana is a pretty active in acting and dancing on his own videos and is going to work with a lot of famous artists in his own upcoming songs 

He says he wants to become a Punjabi cum Bollywood singer and music producer around the world and explore the talent. So keep motivating the songbird , who are chasing their dreams and wishes them the best for their shining future.