This is the era where people crave to look beautiful, post pictures, stand in the limelight, etc. Nadia is an example, who elevates the art of makeup. It is quite difficult for a lot of girls out there to stand confidently and be proud of their physical appearance. Putting on the flawless makeup, blending the right colors and amplifying the beauty is a very strenuous job. Working for Bollywood artists and giving them the meticulous look, is commendable. Not only has she been a dedicated professional but her work will also be acknowledged in upcoming Bollywood projects. We, as an audience, have definitely seen the power of makeup. It can change the entire personality of an individual and also gives the audience a different perspective to watch a movie. It’s all the hard work of a make up artist behind those curtains. 

Nadia White, an inspiring image for complete fitness and one who is setting the standards high for all the make up artists. She is a social figure, who has been motivating the youth in so many different ways. 

Nadia stands up to a quote said by Jim Murphy, “She sees in black and white, thinks in greys, and loves in colors.” What better way to define a passionate make up artist. Her passion and her spirit to enhance the inner beauty of a person through her art is incredible. Not only this, she has been collaboration with brands as a fitness model. Her contribution as a makeup artist will be soon evident in Bollywood ventures. She has been sharing her beauty regime on the internet for all her followers and seekers. Nadia is a recognized individual in her field and she dedicates her time in bringing out the best in an individual through her make up art. 

Her Instagram handle is a proof that she is a believer of good health and care. It is evident from all the posts that she likes to keep her followers updated about her lifestyle as well as the places she has been travelling. Her fitness and her health are also the reason why she looks flawless. She is a gym person and also shares all her pictures working out and maintaining her body and health. Make up does glams up a person but being fit is an inevitable process to look refreshed and glowing. She shares her eating habits and her range of products on these social media websites for her followers to pursue. 

These beauty regimes are a very important part of Nadia’s life. The brands she prefers using and exploring are no secret to people whom she inspires. She have been vocal about them quite a lot on her social media handles. Her way of balancing her personal life as well as being a social figure and managing her professional life is exhilarating. To possess that passion and also work hard towards accomplishing the goals are two very important parts of Nadia’s life. Her husband has been constant support towards her profession and her life. 

“A dream doesn’t become a reality through magic, It takes sweat, determination, and hard work.” Nadia is working tirelessly to achieve her dreams. Her work of precision and art is worth the praise and appreciation that she receives. Giving people a chance at confidence and belief is a huge blessing, that she has been providing to people. Nadia is aspiring make up artist. She believes she still has a lot to achieve in life but her one major goal is to give people the taste of her spirit and her passion. She wants to spread the love of make up and colors and attain the fame and name in the profession with all her hard work.

Sayan Bakshi is the name of the hour! The present social media situation of the country sees a steep rise in the number of Instagram influencers and bloggers. However, amidst the large number, only a handful are a name in the industry, be it for their amazing content, or their massive fan following on social media. Such a name in the industry is, Sayan Bakshi, popularly known as The Orange Epistles. Sayan is a popular name among the country’s bloggers and influencers and pointed to be noted, he is the only male influencer from Kolkata. Sayan works from the cities Mumbai & Kolkata and is generally seen actively creating content for his channels, traveling for work and collaborations, shooting for brands, or anchoring events or television shows.

Let’s take a sneak-peak into The Orange Epistles’ wow life and let’s hear from the blogger himself, what he has to say on quitting his 9-to-5 job, and taking up blogging as a full time career. In an exclusive chat with us, Sayan Bakshi mentions that fashion and glamour were something he was always interested in, and he forever wanted a career in the glamour industry. His parents, being quite liberal, were supportive when Sayan chose to shift to a completely different arena in the profession, than what he had pursued his degree in. His parents were always cautious about his grades and academics, therefore, Sayan had always been a scholar in his school and college. He completed his Masters in Medical Technology in 2016 with a whopping 83%, and thereafter started his internship with a renowned hospital in Mumbai. During his postgrads years and internship, he started blogging, took up an acting course, worked as a print model, and had also appeared in two TV daily soaps. By the end of 2016, he decided to quit his 9-to-5 job as medical personnel, and pursue blogging as his mainstream profession. The talented blogger mentions, “I took this risk for my heart’s content. I am a happy kid when I am working on my own terms, and in my own creative space. I believe that’s how I can learn more and grow. And, being a blogger allows me to do so!”

In today’s day, Sayan Bakshi has now worked with more than 200 brands. The fashion & lifestyle blogger is reaching new heights and coming up with flying colors every single day. His Instagram profile @theorangeepistles is colourfully glamorous, and speaks of fashion, lifestyle, men’s grooming, fitness, travel, entertainment, motivation and experiences. His handsome face, fantastic styling sense, a glam wardrobe and charismatic presence makes him one of the best male influencers of the country.

Life is not that much tough when you have the guts to fight against the odds. Many Indian middle-class people have shown their strength to the world as an emerging talent in various fields. 

Mumbai is a place of dreams where every day, thousands of people come to the city to achieve big in their life. Tushar Yuvraj Kamble famous name from Mumbai who was not born with a silver spoon but he never complained. He made it big with his passion and hard work to make it big in life.  

Tushar is a believer he gives his 100% in whatever he does in life. He is an award-winning painter who has won hearts of many like Yash Chapora and other famous B-town celebrities with his paintings. Tushar is not an ordinary painter he is class when it comes to putting colours on canvas. A beautiful story can be made on his life related to his Painting and his professional career. Painting is his hobby and passion too. He always takes some time out from his busy schedule for his Painting. 

Those who know Tushar personally knows pretty well that his first love is painting in life and then photography. This two thing makes him happy, and he has mastered himself in his hobbies.

He is an IT specialist and works in Dubai. He single-handedly arranges work of five projects. You can call him a one-man army. He has learned a lot in Dubai, especially in IT. He is pretty closed to Dubai’s top names because of his expertise in IT.

What good about Tushar is whatever he does in life he does it with perfection. He never does work with half heart. You will always see him giving 100% in his work, and this is the reason why he is achieved this much in his life.

We recently show a movie on Raja Ravi Varma in B-town. The same story can be made on this guy. His Paintings are just excellent, and he is improving day by day with his experience. When you see him painting, it’s like he is living in a different world were only beautiful colours can be seen and happiness.

It is so good to see an artist who is living a beautiful life by learning new things in IT and enjoying his passion and love of Painting and Photography. He can be the next big name in IT in the near future looking to his growth. Aah! You might get confused by reading this painter, photographer or IT. But this guy has forced us to write on him as he is superb in every department. 

His life philosophy is simple, and he believes in working hard and never left things in halfway whatever he does, he complete that with a magnificent result. He is a man of his words too once he says he will do it means there will no excuse from his side.

Vanit Bakshi from Punjab but living in Moscow from more than last 1 decade sizzled the musical world with his astounding persona and charm and mesmerizing voice a heart touching lyricist/ songwriter.

Vanit has worked with some well-renowned banners and has left no stone unturned to make his entry in Bollywood by growing as an Independent Artist by his continuous efforts.

Extracting immense fame and fan fam from a number of albums, Bakshi is all geared up for his upcoming projects in the pipeline. 

Vanit has written a number of praise songs and poems for b’towns ace celebs like Imtiaz Ali, Tabu, Mohit Chauhan, Sonu Nigam, Alka Yagnik, Ayushmaan Khurrana and many more while his meeting with them during some film festival and musical shows in Moscow.

Vanit Bakshi has also contributed to the social welfare of the country via his songs such as Babul, Maa, Hamara Desh,  Gussa Hai Bharat and many more. His most popular song was Hanju : Tears of Happiness which was released by Zee Music and was Feat.Svetlana Tulasi who is a well-known name in Lovers of Classical / Kathak Dance. Another hit given by Vanit Bakshi was Sajda and cover of “Teri Mitti” from movie Kesari.

Vanit Bakshi’s most awaited song  “Akhaan Jaa Rawayiaan”  will be out soon in which he has collaborated again with Svetlana Tulasi and Surely! his fans can’t wait for it.

Just because your life changes doesn’t mean that your deepest passion has to. Very rare to see such people who follow this rule in their life and the one who has followed has set an example which needs to be praised. As this person has reached the greatest level of success one could not achieve at a very early age as he is just 22 now. His hard work, persistence, and determination really should be appreciated with a pat on the back.

The Pillar of one of the leading Digital Marketing firm DIGIHAKK, Sarvesh Pancholi, born on 12th August 1996 and is based out in Indore. He has faced a lot of challenges to build this empire called DIGIHAKK. They have built some great techniques related to digital marketing. They have spread their roots in Udaipur, Indore, and Ahmedabad by now and focusing on extending their concepts all over so that they can train the youth to grab some exciting position and gain experience in Digital Marketing. The real focus is to build opportunities for others.

There has been a lot of struggle in his life but nothing stopped him. He started off from a very early age. He established his first company when he was just 16 named “SCHOOL SECURITY” which provides training in ethical hacking and services. But this is not been achieved without challenges. The biggest challenge for him was having less experience in this field and most importantly a lot of financial crisis, but by the time he was 18, he reached another milestone by starting off with 3-4 startups. Now that’s a bigger achievement at this less age.”Age factor was an issue. I had to drop out my college and take up this big Risk at the age of 18 which helped me build 3-4 startups. But that failed and now I am proud of myself that I could establish a giant in the Digital Marketing field which is DIGIHAKK”, says Sarvesh.

Learning should never stop. Gaining knowledge and sharing of knowledge is most important in life to reach success. He at present also self trains himself to be better each day by polishing his skills to face new challenges. Hats off to this young man who was been confident in himself believed in his dreams and had a courage to take up the risk.

There is something special to be your own boss and build your own empire. At some point, one needs to start from scratch, and Neha Chatlani is a prime example of it. Based in Bangalore, she holds a degree in MBA and had been a corporate HR recruiter for more than 4 years. While working, she realized that her job had become monotonous and did not give her the right platform to channelize her creative side. 

When being her own boss was more important to her than following someone else’s orders, she decided to take the plunge with YouTube. Along with her job, she simultaneously managed her YouTube channel to unleash her creative side. Juggling multiple things at the same time had become a tedious task. With time, her inclination was shifting towards the creative field in Social Media. She had to make a choice, so she bid adieu to one of the Big 4 audit firms and chose social media as her full-time career.

Through Instagram, she showcased how comfortable outfits could be made stylish, keeping in mind the college and workplace dress codes. Her main focus was street style fashion for which she got an overwhelming response. She started connecting more with her audience through her social media platforms and creating relatable content that suited their needs. Her styling was quickly noticed by brands like Fabindia that invited her to conduct a styling masterclass at one of their branches. She also started a blog called “The Talky Trails” that diversifies into a lifestyle, food, and travel. 

Her main motto which she strongly believes in is “Fashion need not be uncomfortable to be stylish”. As a top fashion influencer, she has worked with more than 500 brands including Reebok, Myntra, Maybelline, Nykaa, Nissan, Holiday Inn and many more. Today she is one of the most successful content creators on social media in Bangalore and is also recognized as a top blogger on Trell – a visual blogging platform.

In today’s time, blogging as a career has become one of the most sought professions. People pursuing engineering or any other degree tend to shift towards the world of blogs. Same happened with Nivrity Das who is one of the most influential bloggers today. Hailing from the city of joy, Kolkata, she has been a school topper and has done B.Tech in electronics and communication. However, she has a deep affection for fashion, beauty, and lifestyle; and her blog is a reflection of whatever she does.

Her blogging journey was a random thought which started off in college. Nivrity had always been intrigued by speaking her heart out and she kept herself up to date with the latest style and fashion trends. Not just experimenting with looks, she also had been very fond of getting clicked. Be it anchoring or managing events at the college, her love to express herself saw her in becoming a top blogger/vlogger.

Speaking about her progress, Nivrity Das believes that her graph as a blogger has been consistently increasing. With just three years in this field, she collaborated with more than 200 brands and is one of the most popular bloggers in Kolkata. Apart from Kolkata, she has done numerous events in Mumbai as well. The thing which interests this fashion influencer the most about her career is to showcase what she loves – be it any travel destination, a lifestyle product or fashion outfits. 

Moreover, Nivrity’s beautiful looks and immense dedication towards work can completely be seen in her content. With having more than 270K followers on Instagram, her feed shows how passionate she is about travel and makeup. Her styling ideas also go with the latest trends which have caught everyone’s eye on social media. If you are a person who loves traveling and follows the latest fashion and lifestyle trends, check out her Instagram feed right away.

Expressing gratitude, she was quoted saying, “I am really grateful to God. Whatever I have got the recognition today is because of the immense love of all my followers.” She did not forget to mention her constant support, her photographer cum confidant, Jyotika Baijal who has been her backbone in creating such marvelous content.

In the 21st century, you need to be the best to beat the giants of this world. We often see so many young talents who have to change the definition of business. There are many talents today who are under 30 and ruling the world like a boss and also return this goodwill back to their community through community service and nonprofit work. 

CEO Ahmad Rashad, a renowned entrepreneur, has made his name from starting his first business with a $10,000 Loan and turned this into millions in a short period of time. Rashad was in 11th grade when he decided to start a company called “Cargado”, which was an energy drink company. At just the young age of 14, Rashad was honored to receive his first major award, the Rice Award. It was his privilege to be recognized at such a young age for all his hard work. 

Next, Rashad ventured into the entertainment industry, but he quickly realized that route was not for him. Then came his stock market journey, where he learned about ForEx and trading. Through his profits he received from trading, he acquired multiple streams of income. Rashad not only trade, but also has residential listings on Airbnb. Furthermore, Rashad has built his own Shopify stores. His earnings grossed $1,00,000 in 2018 and more than 620 people endorsed him and his business. 

After achieving such high success in Forex, Rashad than started his own credit company called “Elite Credit and Business Services.” Through this business, he was able to help individuals receive 3.2 million in business funding. 

 With all the abundant blessings Rashad has received, he believes that it is imperative that he pour these blessings back into his community. He believes in earning, but he also believes in giving back to his community and helping those less fortunate. Rashad has organized many charity events around the city of Atlanta. His most recent event was a back to school giveaway for the kids in which he gave out school supplies, a $500 check, book bags, speakers, headphones and more! 

Rashad wants to be an inspiration to children and show them that they can achieve anything they put their minds to, no matter their age. Rashad is still very young but has accomplished many goals. He wants to teach others how they too can change their lives and make a difference in their communities! Through hard work and dedication, you can achieve anything and Rashad is a prime example of this.

“It’s easy to express but difficult to influence”.

What requires is an ability to influence people, to bring a change in their ideas, perspective and importantly their opinion that what matters a lot. 

Nowadays people have chosen social media which is serving as an independent platform for them to express themselves and influence others. Among many renowned influencers, the first name that strikes to the mind is of the young talent of Bangalore “Sayyed Sohel Torvi”.

Sayyed Sohel Torvi is a 26-year-old entrepreneur, influencer and a magnificent motivational speaker. He is having a large scale Granite export business. Owing to a company named Ababil Granite Pvt.Ltd and have a healthy business relationship with well-developed countries like China and Taiwan. Unlike other Influencers, his modus operandi is somewhat different and appealing.

His positive perspective about life stimulates him to create motivational contents on social media. Commendable oratory skills leading him on the path of becoming an ideal example for the youth of our country. Besides a successful entrepreneur, he is a man of values. He believes in encouraging and inspiring others to hustle hard day and night and achieve the target. His goal is not only to be a successful entrepreneur of this era but also to leave an impact on an ideal number of people through his charismatic temperament.

It is said that a good leader should possess the influential quality to guide his followers, we have a dazzling exemplar “Sayyed Sohel Torvi aka Suhail Rasool”. Yes! His influential disposition made him won the NDIA Leadership Award 2019, that’s sounds amazing.

His power of words and way of expressing himself segregate him from the crowd and making him one of the most puissant personality of the age. From consuming a lot of values and life lessons from the motivational content he has proved himself as a man of his words in the eyes of innumerable people.

Beta-amyloid plaques, the protein aggregates that form in the brains of Alzheimer’s patients, disrupt many brain functions and can kill neurons. They can also damage the blood-brain barrier — the normally tight border that prevents harmful molecules in the bloodstream from entering the brain.

MIT engineers have now developed a tissue model that mimics beta-amyloid’s effects on the blood-brain barrier, and used it to show that this damage can lead molecules such as thrombin, a clotting factor normally found in the bloodstream, to enter the brain and cause additional damage to Alzheimer’s neurons.

“We were able to show clearly in this model that the amyloid-beta secreted by Alzheimer’s disease cells can actually impair barrier function, and once that is impaired, factors are secreted into the brain tissue that can have adverse effects on neuron health,” says Roger Kamm, the Cecil and Ida Green Distinguished Professor of Mechanical and Biological Engineering at MIT.

The researchers also used the tissue model to show that a drug that restores the blood-brain barrier can slow down the cell death seen in Alzheimer’s neurons.

Kamm and Rudolph Tanzi, a professor of neurology at Harvard Medical School and Massachusetts General Hospital, are the senior authors of the study, which appears in the journal Advanced Science. MIT postdoc Yoojin Shin is the paper’s lead author.

Barrier breakdown

The blood vessel cells that make up the blood-brain barrier have many specialized proteins that help them to form tight junctions — cellular structures that act as a strong seal between cells.

Alzheimer’s patients often experience damage to brain blood vessels caused by beta-amyloid proteins, an effect known as cerebral amyloid angiopathy (CAA). It is believed that this damage allows harmful molecules to get into the brain more easily. Kamm decided to study this phenomenon, and its role in Alzheimer’s, by modeling brain and blood vessel tissue on a microfluidic chip.

“What we were trying to do from the start was generate a model that we could use to understand the interactions between Alzheimer’s disease neurons and the brain vasculature,” Kamm says. “Given the fact that there’s been so little success in developing therapeutics that are effective against Alzheimer’s, there has been increased attention paid to CAA over the last couple of years.”

His lab began working on this project several years ago, along with researchers at MGH who had engineered neurons to produce large amounts of beta-amyloid proteins, just like the brain cells of Alzheimer’s patients.

Led by Shin, the researchers devised a way to grow these cells in a microfluidic channel, where they produce and secrete beta-amyloid protein. On the same chip, in a parallel channel, the researchers grew brain endothelial cells, which are the cells that form the blood-brain barrier. An empty channel separated the two channels while each tissue type developed.

After 10 days of cell growth, the researchers added collagen to the central channel separating the two tissue types, which allowed molecules to diffuse from one channel to the other. They found that within three to six days, beta-amyloid proteins secreted by the neurons began to accumulate in the endothelial tissue, which led the cells to become leakier. These cells also showed a decline in proteins that form tight junctions, and an increase in enzymes that break down the extracellular matrix that normally surrounds and supports blood vessels.

As a result of this breakdown in the blood-brain barrier, thrombin was able to pass from blood flowing through the leaky vessels into the Alzheimer’s neurons. Excessive levels of thrombin can harm neurons and lead to cell death.

“We were able to demonstrate this bidirectional signaling between cell types and really solidify things that had been seen previously in animal experiments, but reproduce them in a model system that we can control with much more detail and better fidelity,” Kamm says.

Plugging the leaks

The researchers then decided to test two drugs that have previously been shown to solidify the blood-brain barrier in simpler models of endothelial tissue. Both of these drugs are FDA-approved to treat other conditions. The researchers found that one of these drugs, etodolac, worked very well, while the other, beclomethasone, had little effect on leakiness in their tissue model.

In tissue treated with etodolac, the blood-brain barrier became tighter, and neurons’ survival rates improved. The MIT and MGH team is now working with a drug discovery consortium to look for other drugs that might be able to restore the blood-brain barrier in Alzheimer’s patients.

“We’re starting to use this platform to screen for drugs that have come out of very simple single-cell screens that we now need to validate in a more complex system,” Kamm says. “This approach could offer a new potential form of Alzheimer’s treatment, especially given the fact that so few treatments have been demonstrated to be effective.”

The research was funded by the Cure Alzheimer’s Fund and the JPB Foundation.